Unexplained loss of muscle mass, known as cachexia, is a complex condition involving metabolic dysfunction that causes drastic wasting of skeletal muscle. While cachexia commonly accompanies cancer, AIDS, kidney disease, and heart failure, it also mysteriously strikes people without other known illnesses.
What causes cachexia? Simply put, an imbalance between muscle protein build-up and breakdown. But many intertwining factors underlie that imbalance, including:
- Inflammation - High cytokines like IL-6 and TNF-alpha
- Insulin resistance - Impairs muscle growth signaling
- Anemia - Low RBCs and oxygen to muscles
- Appetite loss and nutritional deficiencies
The triggers behind these cachexia contributors remain largely unknown in many patients. Genetics likely play a role as well.
How is cachexia diagnosed? Doctors assess symptoms like
rapid weight and muscle loss, fatigue, loss of appetite and muscle weakness along with blood tests for things like
anemia,
high CRP as an inflammation marker, and low serum albumin indicating malnutrition. They also examine whether known cachexia culprits like cancer or heart failure are present. Imaging like CT scans can quantify
muscle wasting.
Can cachexia be treated? Potential
cachexia treatments aim to improve nutrition, exercise capacity, inflammation, anemia and muscle signaling - but results vary. New Beginnings HRT Clinic specializes in using
testosterone therapy to help rebuild wasting muscles in cachectic patients through expert hormone balancing. Our physicians personalize multi-prong treatment plans to combat cachexia’s complex causes.
While research continues on cachexia’s enigmatic mechanisms, support groups can help patients and families cope with its frustrating and disabling effects. Seeking an accurate diagnosis from a doctor at the first signs of unexplained
muscle loss and fatigue is crucial to slow further wasting. At New Beginnings HRT Clinic, we provide compassionate care for those with cachexia and
empower patients with knowledge and
treatment options tailored to their needs.